Colchicine-Induced Allo- and Autopolyploidy in Nicotiana

autopolyploidy and parthenogenesis in animals

6 1 Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), 7 Im Neuenheimer Feld 580, 69120 Heidelberg, Germany 8 2 Institute for Environmental Sciences, University of Koblenz-Landau, Forststrasse 7, 76829 9 Landau, Germany 10 3 Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, 11 Staudingerweg 5, 55128 Mainz, Germany 12 * present address: ...

Hydroxychloroquine and colchicine induced myopathy.

Colchicine-induced myopathy and neuropathy.

Myopathy and neuropathy that have been induced by colchicine have been described only occasionally, although colchicine is a widely used drug. We describe a case of colchicine-induced myopathy and neuropathy in an 84-year-old woman who had renal impairment. Results from a muscle biopsy showed characteristic vacuolar myopathy and autophagic vacuoles. The cessation of medication resulted in a mar...

Combining Transcriptome Assemblies from Multiple De Novo Assemblers in the Allo-Tetraploid Plant Nicotiana benthamiana

BACKGROUND Nicotiana benthamiana is an allo-tetraploid plant, which can be challenging for de novo transcriptome assemblies due to homeologous and duplicated gene copies. Transcripts generated from such genes can be distinct yet highly similar in sequence, with markedly differing expression levels. This can lead to unassembled, partially assembled or mis-assembled contigs. Due to the different ...

Colchicine-Induced Hepatotoxicity

Drug-induced injury (DILI) is a frequent cause of abnormal liver tests and a leading cause of liver failure in the United States. Colchicine has long been used as a systemic anti-inflammatory agent for treatment of gout by inhibiting mitotic activity and neutrophil function. We present the first case of colchicine-induced hepatoxicity, supported by histopathologic findings characteristic of col...